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Literature summary for 2.4.1.17 extracted from

  • Green, M.D.; Belanger, G.; Hum, D.W.; Belanger, A.; Tephly, T.R.
    Glucuronidation of opioids, carboxylic acid-containing drugs, and hydroxylated xenobiotics catalyzed by expressed monkey UDP-glucuronosyltransferase 2B9 protein (1997), Drug Metab. Dispos., 25, 1389-1394.
    View publication on PubMed
Search for more literature for 2.4.1.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
 naloxone apparent Km for UGT1B9 Macaca fascicularis
0.048
-
 naloxone apparent Km for UGT1B9, second determination Macaca fascicularis
0.05
-
 Naltrexone apparent Km for UGT1B9 Macaca fascicularis
0.06
-
 nalorphine apparent Km for UGT1B9 Macaca fascicularis
0.065
-
 nalorphine apparent Km for UGT1B9, second determination Macaca fascicularis
0.067
-
 Naltrexone apparent Km for UGT1B9, second determination Macaca fascicularis
0.156
-
 codeine apparent Km for UGT1B9, second determination Macaca fascicularis
0.239
-
 codeine apparent Km for UGT1B9 Macaca fascicularis
0.33
-
 morphine apparent Km for UGT1B9, formation of 3-glucuronide Macaca fascicularis
0.702
-
 oxymorphone apparent Km for UGT1B9 Macaca fascicularis
0.775
-
 oxymorphone apparent Km for UGT1B9, second determination Macaca fascicularis
0.98
-
 dihydromorphine apparent Km for UGT1B9 Macaca fascicularis
1.39
-
 dihydromorphone apparent Km for UGT1B9 Macaca fascicularis

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca fascicularis
-
 cynomolgus monkey
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androsterone + UDPglucuronate
-
 Homo sapiens UDP + androsterone O-glucuronide
-
 ?
androsterone + UDPglucuronate
-
 Macaca fascicularis UDP + androsterone O-glucuronide
-
 ?
borneol + UDPglucuronate
-
 Homo sapiens UDP + borneol O-glucuronide
-
 ?
borneol + UDPglucuronate other 7 monoterpenoid alcohols show substrate activity with UGT2B9 Macaca fascicularis UDP + borneol O-glucuronide
-
 ?
buprenorphine + UDPglucuronate
-
 Homo sapiens UDP + buprenorphine O-glucuronide
-
 ?
buprenorphine + UDPglucuronate
-
 Macaca fascicularis UDP + buprenorphine O-glucuronide
-
 ?
clofibrate + UDPglucuronate
-
 Macaca fascicularis UDP + ?
-
 ?
clofibrate + UDPglucuronate glucuronidated by UGT2B7 Homo sapiens UDP + ?
-
 ?
codeine + UDP-glucuronate
-
 Macaca fascicularis codeine beta-D-glucuronide + UDP
-
 ?
dihydromorphine + UDPglucuronate
-
 Macaca fascicularis UDP + dihydromorphine O-glucuronide
-
 ?
dihydromorphone + UDPglucuronate
-
 Macaca fascicularis UDP + dihydromorphone O-glucuronide
-
 ?
dihydrotestosterone + UDPglucuronate
-
 Macaca fascicularis UDP + dihydrotestosterone O-glucuronide
-
 ?
hyodeoxycholic acid + UDPglucuronate
-
 Homo sapiens UDP + hyodeoxycholic acid O-glucuronide
-
 ?
hyodeoxycholic acid + UDPglucuronate UGT2B9 glucuronidates hyodeoxycholate Macaca fascicularis UDP + hyodeoxycholic acid O-glucuronide
-
 ?
ibuprofen + UDPglucuronate
-
 Homo sapiens UDP + ?
-
 ?
ibuprofen + UDPglucuronate R and S isomers tested separately Macaca fascicularis UDP + ?
-
 ?
morphine + UDP-glucuronate
-
 Homo sapiens UDP + morphine 3,6-diglucuronide
-
 ?
morphine + UDP-glucuronate 3 and 6-glucuronide formation with UGT2B9, other 9 morphian opioids can act as substrates Macaca fascicularis UDP + morphine 3,6-diglucuronide
-
 ?
nalorphine + UDPglucuronate
-
 Macaca fascicularis UDP + nalorphine O-glucuronate
-
 ?
naloxone + UDPglucuronate
-
 Macaca fascicularis UDP + naloxone O-glucuronide
-
 ?
naltrexone + UDPglucuronate
-
 Macaca fascicularis UDP + naltrexone O-glucuronide
-
 ?
oxymorphone + UDPglucuronate
-
 Macaca fascicularis UDP + oxymorphone O-glucuronide
-
 ?
profen + UDPglucuronate
-
 Macaca fascicularis UDP + ?
-
 ?
profen + UDPglucuronate glucuronidated by UGT2B7 Homo sapiens UDP + ?
-
 ?
testosterone + UDPglucuronate other 17 hydroxylated androgens tested Macaca fascicularis UDP + testosterone O-glucuronide
-
 ?
valproic acid + UDPglucuronate
-
 Macaca fascicularis UDP + ?
-
 ?
valproic acid + UDPglucuronate glucuronidated by UGT2B7 Homo sapiens UDP + ?
-
 ?