Any feedback?
Literature summary for 2.4.1.17 extracted from
- UDP-glucuronosyltransferases (1989), Pharmacol. Ther., 43, 261-289.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Clofibrate | induces activity of bilirubin-UDPGT | Homo sapiens |  |
| Clofibrate | induces activity of bilirubin-UDPGT | Rattus norvegicus | |
| Phenobarbital | induces activity towards morphine, chloramphenicol, bilirubin and certain steroids | Rattus norvegicus | |
| Phenobarbital | induces activities towards bilirubin and 1-naphthol whereas does not affect activities against morphine and chloramphenicol | Homo sapiens | |
| polycyclic aromatic hydrocarbons | induce activity towards simple phenols such as 1-naphthol, 2-aminophenol and mitoxantrone | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells | Rattus norvegicus |
| expressed in COS-7-H25 and HP1 cells | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| extremely unstable during purification | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
phenol-UDPGT, only isoform detectable in fetal rat liver microsomes | Rattus norvegicus |
| 53000 | - |
x * 53000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with estradiol as a specific substrate | Homo sapiens |
| 54000 | - |
bilirubin-UDPGT, detectable after birth | Rattus norvegicus |
| 54000 | - |
x * 54000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with 4-aminobiphenyl as a specific substrate | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
| additional information | Homo sapiens | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
| additional information | Rattus norvegicus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
overview | - |
| Mus musculus | - |
mouse, overview | - |
| Rattus norvegicus | - |
overview | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| several methods including chromatofocusing, combined with anion exchange chromatography and/or affinity chromatography of UDP-hexanolamine Sepharose | Rattus norvegicus |
| two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,7,7-triphenylheptanoic acid + UDPglucuronate | - |
Rattus norvegicus | UDP + 7,7,7-triphenylheptanoic acid glucuronide | - |
? | |
| bilirubin + UDPglucuronate | Gunn strain liver enzyme inactive | Rattus norvegicus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Mus musculus | ? | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Homo sapiens | ? | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Rattus norvegicus | ? | - |
? | |
| morphine + UDP-glucuronate | - |
Mus musculus | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | - |
Homo sapiens | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 54000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with 4-aminobiphenyl as a specific substrate | Homo sapiens |
| ? | x * 53000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with estradiol as a specific substrate | Homo sapiens |
| ? | all values determined by SDS-PAGE | Mus musculus |
| ? | all values determined by SDS-PAGE | Homo sapiens |
| ? | all values determined by SDS-PAGE | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
