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Literature summary for 2.4.1.17 extracted from

  • Crawford, J.M.; Ransil, B.J.; Narciso, J.P.; Gollan, J.L.
    Hepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis (1992), J. Biol. Chem., 267, 16943-16950.
    View publication on PubMed
Search for more literature for 2.4.1.17

Inhibitors

Inhibitors Comment Organism Structure
bilirubin diglucuronides competitive inhibitors Rattus norvegicus
bilirubin monoglucuronides competitive inhibitors Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0137
-
 bilirubin conversion to bilirubin monoglucuronide Rattus norvegicus
0.0193
-
 bilirubin conversion to bilirubin diglucuronide Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Rattus norvegicus 5789
-
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + UDPglucuronate Rattus norvegicus physiological elimination of bilirubin UDP + bilirubin O-glucuronide
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + UDPglucuronate
-
 Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate physiological elimination of bilirubin Rattus norvegicus UDP + bilirubin O-glucuronide
-
 ?
bilirubin monoglucuronide + UDPglucuronate
-
 Rattus norvegicus bilirubin diglucuronide + UDP
-
 ?