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Literature summary for 2.4.1.149 extracted from

  • Kataoka, K.; Huh, N.h.
    A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro (2002), Biochem. Biophys. Res. Commun., 294, 843-848.
    View publication on PubMed
Search for more literature for 2.4.1.149

Application

Application Comment Organism
medicine enzyme may be used as diagnostic marker of human cancer or as target molecule for the development of a new therapy Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
cDNA from placenta encoding beta3GnT7 is cloned and partially characterized, open reading frame encodes a 397-amino acids protein Mus musculus
human ortholog to mouse enzyme beta3GnT7 has the chromosomal locus 2q37.1 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 x * 45000, calculated from the amino acid sequence Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues ?
-
 ?
additional information Mus musculus beta3GnT7 beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NFL0
-
-
Mus musculus Q8K0J2 beta3GnT7
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Mus musculus beta3GnT7 Q8K0J2 beta3GnT7
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum very weak expression of beta3GnT7 Mus musculus
-
cerebrum very weak expression of beta3GnT7 Mus musculus
-
colon beta3GnT7 is most strongly expressed in the placenta and colon Mus musculus
-
FM3A cell breast cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness Mus musculus
-
heart very weak expression of beta3GnT7 Mus musculus
-
kidney moderate expression of beta3GnT7 Mus musculus
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KLN205 cell KLN205-MUC1, lung cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness Mus musculus
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lung moderate expression of beta3GnT7 Mus musculus
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placenta beta3GnT7 is most strongly expressed in the placenta at the later stages of gestation and in colon Mus musculus
-
small intestine moderate expression of beta3GnT7 Mus musculus
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stomach moderate expression of beta3GnT7 Mus musculus
-
testis very weak expression of beta3GnT7 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues Mus musculus ?
-
 ?
additional information beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues Mus musculus beta3GnT7 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, calculated from the amino acid sequence Mus musculus

Synonyms

Synonyms Comment Organism
beta3GnT7
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 pI: 8.7 Mus musculus