Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.129 extracted from

  • Egan, A.J.; Biboy, J.; vant Veer, I.; Breukink, E.; Vollmer, W.
    Activities and regulation of peptidoglycan synthases (2015), Philos. Trans. R. Soc. Lond. B Biol. Sci., 370, 20150031.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
peptidoglycan-based cell wall murein sacculus Escherichia coli 9274
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli lipid II, i.e. undecaprenyl-diphosphoryl-MurNAc(pentapeptide)-GlcNAc, is polymerized by the glycosyltransferase reaction, under the release of undecaprenol diphosphate ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P02919
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lipid II, i.e. undecaprenyl-diphosphoryl-MurNAc(pentapeptide)-GlcNAc, is polymerized by the glycosyltransferase reaction, under the release of undecaprenol diphosphate Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
PBP1b
-
Escherichia coli
penicillin-binding protein 1B
-
Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme is involved in synthesis of peptidoglycan, a key cell wall component in nearly all bacteria, protecting the cell from bursting by its internal turgor and maintaining cell shape. Peptidoglycan consists of glycan strands connected by short peptides and forms a continuous, mesh-like structure around the cytoplasmic membrane, called the sacculus. In Gram-negative species, such as Escherichia coli, the sacculus is made of a mainly single layer of peptidoglycan with a thickness of 3-6 nm. The glycan strands are made of alternating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) residues linked by beta-1,4 glyosidic bonds. The peptides contain L- and D-amino acids and are linked to MurNAc residues. The sequence is L-Ala-D-iGlu-m-Dap-D-Ala-D-Ala (m-Dap, meso-diaminopimelic acid). During cell growth and division, the surface of the sacculus is enlarged by the incorporation of new peptidoglycan material. In this process, the precursor lipid II (undecaprenyl-diphosphoryl-MurNAc(pentapeptide)-GlcNAc) is polymerized by the glycosyltransferase reaction of the GTase domain of enzyme PBP1B Escherichia coli