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Literature summary for 2.4.1.129 extracted from

  • Yuan, Y.; Fuse, S.; Ostash, B.; Sliz, P.; Kahne, D.; Walker, S.
    Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design (2008), ACS Chem. Biol., 3, 429-436.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.129

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of neryl-moenomycin A bound to the peptidoglycan glycosyltransferase domain of PBP1A Aquifex aeolicus

Protein Variants

Protein Variants Comment Organism
E83A mutant with undetectable activity Aquifex aeolicus
K124A mutant shows 5fold reduced activity compared to the wild type enzyme Aquifex aeolicus
K137A mutant with undetectable activity Aquifex aeolicus
Q121A mutant with undetectable activity Aquifex aeolicus
R132A mutant with barely detectable activity (about 3% of wild type) Aquifex aeolicus
S116A mutant shows 10fold reduced activity compared to the wild type enzyme Aquifex aeolicus

Inhibitors

Inhibitors Comment Organism Structure
moenomycin A active site inhibitor Aquifex aeolicus
neryl-moenomycin A active site inhibitor Aquifex aeolicus

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus O66874
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Aquifex aeolicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Aquifex aeolicus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PBP1a
-
 Aquifex aeolicus
PGT
-
 Aquifex aeolicus