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Literature summary for 2.4.1.129 extracted from

  • Garneau, S.; Qiao, L.; Chen, L.; Walker, S.; Vederas, J.C.
    Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b (2004), Bioorg. Med. Chem., 12, 6473-6494.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R,3'R)-3-(3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)propylphosphinato)-2-(3',7'-dimethyloctyloxy)propanoic acid 0.1 mM, 25% inhibition, 0.2 mM, 37% inhibition Escherichia coli
(2R,3'R)-3-[3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)propylphosphinato]-2-(3',7'-dimethyloctyloxy)propanoic acid 0.1 mM., 25% inhibition, 0.2 mM, 61% inhibition Escherichia coli
(R)-3-((2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-alpha-D-glucopyranosyl)methylphosphinato)-2-octyloxypropanoic acid 0.1 mM, 17% inhibition Escherichia coli
(R)-3-[3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl)propylphosphinato]-2-octyloxypropanoic acid 0.1 mM, 10% inhibition Escherichia coli
(Z)-2-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxymethyl-3-tetradecylbutenedioic acid dilithium salt 0.1 mM, 28% inhibition Escherichia coli
(Z)-2-farnesyl-3-methylbutenedioic acid dilithium salt weak inhibition Escherichia coli
(Z)-2-geranyl-3-methylbutenedioic acid dilithium salt 0.1 mM, 12% inhibition Escherichia coli
(Z)-2-nerolyl-3-methylbutenedioic acid dilithium salt 0.1 mM, 17% inhibition Escherichia coli
chaetomellic acid A dilithium salt weak inhibition Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli penicillin-binding protein 1b is the key enzyme responsible for the formation of the polysaccharide backbone of the peptidoglycan as well as for cross-linking of its peptide portion ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information penicillin-binding protein 1b is the key enzyme responsible for the formation of the polysaccharide backbone of the peptidoglycan as well as for cross-linking of its peptide portion Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
PBP1b
-
Escherichia coli
penicillin-binding protein 1B
-
Escherichia coli