Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
S10A | phosphorylation mutant. Mutation does not cause singnificant changes in the activation state | Rattus norvegicus |
S640A | phosphorylation mutant, moderate increase in the activity ratio | Rattus norvegicus |
S644A | phosphorylation mutant, moderate increase in the activity ratio | Rattus norvegicus |
S648A | phosphorylation mutant. Mutation does not cause singnificant changes in the activation state | Rattus norvegicus |
S652A | phosphorylation mutant. Mutation does not cause singnificant changes in the activation state | Rattus norvegicus |
S656A | phosphorylation mutant. Mutation does not cause singnificant changes in the activation state | Rattus norvegicus |
S7A | phosphorylation mutant, large increase in the activity ratio both in soluble and insoluble fraction. Enzyme is almost fully active and able to induce glycogen deposition in primary hepatocytes incubated in the absence of glucose and in FTO2B cells, a cell line that does not normallysynthesize glycogen. Mutation is also sufficient to trigger the aggregation and translocation of liver glycogen synthase from the cytoplasm to the hepatocyte cell cortex in the absence of glucose | Rattus norvegicus |
S7A/E509A | phosphorylation and active site mutant. Translocation of liver glycogen synthase from the cytoplasm to the hepatocyte cell cortex in the absence of glucose is not observed | Rattus norvegicus |
S7A/S10A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
S7A/S640A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
S7A/S644A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
S7A/S648A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
S7A/S652A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
S7A/S656A | phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
FTO-2B cell | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |