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Literature summary for 2.4.1.11 extracted from
- Yeast glycogen synthetase in the glucose 6-phosphate-dependent form. I. Purification and properties (1974), J. Biol. Chem., 249, 3851-3857.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiobis-(2-nitrobenzoic acid) | 77% inactivation at 1 mM | Saccharomyces cerevisiae |  |
| iodoacetate | 10% inactivation at 10 mM | Saccharomyces cerevisiae | |
| iodobenzoate | 22% inactivation at 1 mM | Saccharomyces cerevisiae | |
| N-ethylmaleimide | 83% inactivation at 3 mM | Saccharomyces cerevisiae | |
| p-chloromercuribenzoate | 90% inactivation at 0.01 mM, dithiothreitol reverses | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | 1.1 | UDP-glucose | value dependent on glucose 6-phosphate | Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 77000 | - |
4 * 77000, SDS-PAGE | Saccharomyces cerevisiae |
| 300000 | 310000 | sedimentation equilibrium | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | Saccharomyces cerevisiae | - |
glycogen + UDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | incorporation of 1.4 phosphate groups per subunit | Saccharomyces cerevisiae |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Saccharomyces cerevisiae | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 90.5 | - |
- |
Saccharomyces cerevisiae |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 45 mM Tris/HCl buffer, pH 7.5, 1 mM 2-mercaptoethanol, 10% glycerol, several months | Saccharomyces cerevisiae |
| -20°C, stable for several months | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucose + glycogen | - |
Saccharomyces cerevisiae | glycogen + UDP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 77000, SDS-PAGE | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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