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Literature summary for 2.4.1.11 extracted from

  • Peng, Z.Y.; Trumbly, R.J.; Reimann, E.M.
    Purification and characterization of glycogen synthase from a glycogen-deficient strain of Saccharomyces cerevisiae (1990), J. Biol. Chem., 265, 13871-13877.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Li+ wild-type but not mutant enzyme Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000 310000 gel filtration Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + glycogen Saccharomyces cerevisiae
-
glycogen + UDP
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
glycogen deficient mutant strain and wild-type
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Saccharomyces cerevisiae
phosphoprotein incorporation of 3 phosphates per subunit Saccharomyces cerevisiae
phosphoprotein phosphorylation leads to loss of activity Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
22.85
-
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + glycogen
-
Saccharomyces cerevisiae glycogen + UDP
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 76000-83000, SDS-PAGE Saccharomyces cerevisiae