Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | SIRT3 deacetylates and activates citrate synhase activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | enzymatic activities of citrate synthase and isocitrate dehydrogenase IDH2 are significantly reduced in methyl 4 phenylpyridinium treatment cells, while protein acetylation of citrate synthase and IDH2 increase. Overexpressed sirtuin SIRT3 partially reverses at least, the decline of citrate synthase activity and the increase of citrate synthase protein acetylation | Homo sapiens |