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Literature summary for 2.3.2.8 extracted from

  • Singh, K.; Gupta, A.; Sarkar, A.; Gupta, I.; Rana, S.; Sarkar, S.; Khan, S.
    Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway (2020), Sci. Rep., 10, 598 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.8

Application

Application Comment Organism
medicine the inhibition of ATE1 activity may provide an approach for the treatment of cardiac hypertrophy in humans Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
gene ATE1, quantitative real-time-PCR expression analysis in H9C2 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information for the generation of ATE1 knockdown hypertrophied rats, ATE1 siRNA is encapsulated in stearic acid-modified carboxy methyl chitosan (CMC) conjugated to a cardiomyocyte-targeting peptide. Cardiac function is improved in terms of left ventricular diastolic dysfunction (LVDd) and fractional shortening (%FS) in the ligated + ATE1-siRNA as compared to the Ligated + NS-siRNA when examined by M-Mode echocardiography. Cardiac ATE1 deficiency restores cardiac dysfunction after right renal artery ligation. ATE1 knockdown H9C2 cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle fiber
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 Rattus norvegicus
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H9c2 cell quantitative real-time-PCR expression analysis of ATE1 Rattus norvegicus
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heart enhanced ATE1 expression in hypertrophied heart samples, quantitative real-time-PCR expression analysis Rattus norvegicus
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Synonyms

Synonyms Comment Organism
Ate1
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus ATE1 expression is upregulated by hypertrophic stimuli, increase in ATE1 expression upon hypertrophic stress up

General Information

General Information Comment Organism
evolution arginyltransferase (ATE1) is an evolutionary conserved enzyme Rattus norvegicus
malfunction knockdown of arginyltransferase ATE1 attenuates cardiac hypertrophy and fibrosis in vitro and in vivo through the TAK1-JNK1/2 pathway. The cardioprotective role of ATE1 silencing is mediated by the interruption of TAK1 activity-dependent JNK1/2 signaling pathway. The MAPK signaling cascade is one of the signaling pathways involved in cardiac hypertrophy. ATE1 knockdown in presence of cardiac stress performs a cardioprotective action. Cardiac ATE1 deficiency restores cardiac dysfunction after right renal artery ligation. Phenotype, overview Rattus norvegicus
physiological function arginyltransferase ATE1 can modulate the hypertrophic growth of myocytes induced by Ang II. Physiological importance of ATE1 in higher eukaryotes Rattus norvegicus