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Literature summary for 2.3.2.2 extracted from
- gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 3. IFCC reference method (provisional) (1983), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 3, 357-364.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-(L-alpha-glutamylamino)-2-nitrobenzoic acid | weak | Homo sapiens |  |
| 5-(L-gamma-glutamylamino)-2-nitrobenzoic acid | enzyme from human tissues, not serum | Homo sapiens | |
| additional information | - |
Homo sapiens | |
| Tris(hydroxymethyl)aminomethane | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.65 | - |
5-L-glutamyl 3-carboxy-4-nitroanilide | - |
Homo sapiens | |
| 3.61 | - |
D-Glu-3-carboxy-4-nitroanilide | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | serum | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay method | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, 9 months | Homo sapiens |
| 4°C, at least 5 days | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5-L-glutamyl)-peptide + acceptor + H+ | donor binding site reacts with L- and to a lesser extent D-enantiomer | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
ir | |
| (5-L-glutamyl)-peptide + acceptor + H+ | strict L-stereospecificity of 5-Glu-acceptor site | Homo sapiens | peptide + 5-L-glutamyl amino acid | - |
ir | |
| 5-D-glutamyl 3-carboxy-4-nitroanilide + glycylglycine | - |
Homo sapiens | 5-D-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
| 5-L-glutamyl 3-carboxy-4-nitroanilide + glucana | - |
Homo sapiens | 5-amino-2-nitrobenzoic acid + N-(3-carboxy-4-nitrophenyl)-L-glutaminyl-L-glutamic acid | - |
ir | |
| 5-L-glutamyl 3-carboxy-4-nitroanilide + glycylglycine | - |
Homo sapiens | 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
| 5-L-glutamyl 3-carboxy-4-nitronailide + glycylglycine | - |
Homo sapiens | 5-amino-2-nitrobenzoic acid + 5-L-glutamylglycylglycine | - |
ir | |
| 5-L-glutamyl-3-carboxy-4-nitroanilide + 5-L-glutamyl-3-carboxy-4-nitroanilide | - |
Homo sapiens | 5-L-glutamyl-5-L-glutamyl-3-carboxy-4-nitroanilide + 3-carboxy-4-nitroaniline | - |
? | |
| 5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine | - |
Homo sapiens | 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline | - |
? | |
| 5-L-glutamyl-4-nitroanilide + glycylglycine | - |
Homo sapiens | 4-nitroaniline + 5-L-glutamylglycylglycine | - |
ir | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.9 | - |
- |
Homo sapiens |
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