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Literature summary for 2.3.2.2 extracted from

  • Shaw, L.M.
    gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 1. General (1983), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 3, 349-352.
No PubMed abstract available
Search for more literature for 2.3.2.2

Inhibitors

Inhibitors Comment Organism Structure
5-(L-gamma-glutamylamino)-2-nitrobenzoic acid enzyme from human tissues, not serum Homo sapiens
glycine
-
 Homo sapiens
glycine
-
 Rattus norvegicus
glycylglycine
-
 Homo sapiens
glycylglycine
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular
-
 Rattus norvegicus
-
-
membrane extrinsic to plasma membrane Homo sapiens 16020
-
membrane extrinsic to plasma membrane Rattus norvegicus 16020
-
membrane extrinsic to plasma membrane Oryctolagus cuniculus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + an amino acid Homo sapiens involved in 5-L-glutamyl cycle of glutathione metabolism L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?
glutathione + an amino acid Oryctolagus cuniculus involved in 5-L-glutamyl cycle of glutathione metabolism L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein rich in carbohydrates Homo sapiens
glycoprotein rich in carbohydrates Rattus norvegicus
glycoprotein rich in carbohydrates Oryctolagus cuniculus

Reaction

Reaction Comment Organism Reaction ID
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site on small subunit Homo sapiens
a
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site on small subunit Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
blood serum Homo sapiens
-
duodenum
-
 Homo sapiens
-
duodenum
-
 Rattus norvegicus
-
duodenum
-
 Oryctolagus cuniculus
-
epithelium proximal tubular Rattus norvegicus
-
intestine
-
 Homo sapiens
-
intestine
-
 Rattus norvegicus
-
intestine
-
 Oryctolagus cuniculus
-
kidney luminal membrane of proximal tubules Homo sapiens
-
kidney luminal membrane of proximal tubules Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-
lymphoid cell
-
 Homo sapiens
-
pancreas
-
 Rattus norvegicus
-
pancreas
-
 Oryctolagus cuniculus
-
pancreas acinar cells, apical part Homo sapiens
-
prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Homo sapiens 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Rattus norvegicus 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Oryctolagus cuniculus 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Homo sapiens 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Oryctolagus cuniculus 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
5-L-glutamyl-4-nitroanilide + L-cystine
-
 Homo sapiens 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
5-L-glutamyl-4-nitroanilide + L-cystine
-
 Rattus norvegicus 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
5-L-glutamyl-4-nitroanilide + L-cystine
-
 Oryctolagus cuniculus 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
glutathione + acceptor
-
 Homo sapiens cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
glutathione + acceptor
-
 Rattus norvegicus cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
glutathione + acceptor
-
 Oryctolagus cuniculus cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
glutathione + an amino acid involved in 5-L-glutamyl cycle of glutathione metabolism Homo sapiens L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?
glutathione + an amino acid involved in 5-L-glutamyl cycle of glutathione metabolism Oryctolagus cuniculus L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Subunits

Subunits Comment Organism
More the active site resides on the small subunit Homo sapiens
More the active site resides on the small subunit Rattus norvegicus