Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Streptococcus suis |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 0.2 M sodium chloride, 0.1 M HEPES, pH 7.2, 20% (w/v) polyethylene glycol 4000 | Streptococcus suis |
Protein Variants | Comment | Organism |
---|---|---|
C302A | the mutant shows dramatically decreasing activity compared to the wild type enzyme | Streptococcus suis |
D348A | the mutant shows dramatically decreasing activity compared to the wild type enzyme | Streptococcus suis |
H333A | the mutant shows dramatically decreasing activity compared to the wild type enzyme | Streptococcus suis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus suis | A5JSJ3 | serotype 2 | - |
Purification (Comment) | Organism |
---|---|
glutathione affinity column chromatography | Streptococcus suis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-carbobenzoxy-Gln-Gly + cadaverine | - |
Streptococcus suis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Streptococcus suis |
Synonyms | Comment | Organism |
---|---|---|
TGase | - |
Streptococcus suis |
transglutaminase | - |
Streptococcus suis |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inactivation significantly reduces the virulence of Streptococcus suis serotype 2 in a pig infection model and impairs its antiphagocytosis in human blood | Streptococcus suis |
physiological function | the enzyme is a virulence factor in Streptococcus suis serotype 2 with antiphagocytic activity | Streptococcus suis |