Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-N-(((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methyl)-2-(1-(dimethylamino)naphthalene-5-sulfonamido)-3-(1H-indol-3-yl)propanamide | the majority of cellular TG2 cannot be inhibited in intact cells. The inhibitor potently inhibits cell lysate TG2 activity in the presence of calcium | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the majority of extracellular TG2 is inactive under normal physiological conditions in cell culture and in vivo. Physical or certain types of chemical injury can lead to rapid enzymatic activation | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcium in the putrescine incorporation assay buffer results in activation of previously latent TG2 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine mucosa | acute poly(I:C) injury results in rapid TG2 activation | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
TG2 | - |
Mus musculus |
transglutaminase 2 | - |
Mus musculus |