Cloned (Comment) | Organism |
---|---|
cloning of factor XIII beta-subunit cDNA | Homo sapiens |
liver transglutaminase C | Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Cavia porcellus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
73183 | - |
x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence | Homo sapiens |
75000 | - |
75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits | Homo sapiens |
76620 | - |
1 * 76620, liver transglutaminase, deduced from nucleotide sequence | Cavia porcellus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein-bound gamma-glutamine + alkylamine | Homo sapiens | dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | Cavia porcellus | production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum | protein N5-alkylglutamine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | - |
Cavia porcellus |
additional information | alpha-subunit of factor XIIIa is most probably not glycosylated | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Cavia porcellus | |
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | uterus, macrophages | Homo sapiens | - |
blood platelet | placenta | Homo sapiens | - |
placenta | platelets | Homo sapiens | - |
placenta | macrophages | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein-bound gamma-glutamine + alkylamine | dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence | Homo sapiens |
monomer | - |
Homo sapiens |
monomer | 1 * 76620, liver transglutaminase, deduced from nucleotide sequence | Cavia porcellus |
More | zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively | Homo sapiens |
More | 75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits | Homo sapiens |
More | tissue-type and epidermal TG are monomers, hair follicle TG and coagulation factor XIIIa, i.e. fibrinoligase, are dimers | Homo sapiens |