Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.13 extracted from

  • Ichinose, A.; Bottenus, R.E.; Davie, E.W.
    Structure of transglutaminases (1990), J. Biol. Chem., 265, 13411-13414.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning of factor XIII beta-subunit cDNA Homo sapiens
liver transglutaminase C Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Cavia porcellus 5737
-
cytoplasm
-
Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
73183
-
x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence Homo sapiens
75000
-
75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits Homo sapiens
76620
-
1 * 76620, liver transglutaminase, deduced from nucleotide sequence Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein-bound gamma-glutamine + alkylamine Homo sapiens dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine Cavia porcellus production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum protein N5-alkylglutamine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information
-
Cavia porcellus
additional information alpha-subunit of factor XIIIa is most probably not glycosylated Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Cavia porcellus
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet uterus, macrophages Homo sapiens
-
blood platelet placenta Homo sapiens
-
placenta platelets Homo sapiens
-
placenta macrophages Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein-bound gamma-glutamine + alkylamine dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa Homo sapiens protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum Cavia porcellus protein N5-alkylglutamine + NH3
-
?

Subunits

Subunits Comment Organism
? x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence Homo sapiens
monomer
-
Homo sapiens
monomer 1 * 76620, liver transglutaminase, deduced from nucleotide sequence Cavia porcellus
More zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively Homo sapiens
More 75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits Homo sapiens
More tissue-type and epidermal TG are monomers, hair follicle TG and coagulation factor XIIIa, i.e. fibrinoligase, are dimers Homo sapiens