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Literature summary for 2.3.1.85 extracted from

  • Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
    Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity (2013), J. Enzyme Inhib. Med. Chem., 28, 565-568.
    View publication on PubMed
Search for more literature for 2.3.1.85

Inhibitors

Inhibitors Comment Organism Structure
adriamycin cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.0035 mM, for A-549 cell 0.0018 mM, for HL-60 cell 0.0008 mM Homo sapiens
cerulenin
-
 Gallus gallus
ginkgolic acid C15:1 DELTA8 and DELTA10 isomers, at ratio 1:2 Gallus gallus
ginkgolic acid C15:1 DELTA8 and DELTA10 isomers, at ratio 1:2. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.146 mM, for A-549 cell 0.066 mM, for HL-60 cell 0.005 mM Homo sapiens
ginkgolic acid C17:1 double bond positions not specified Gallus gallus
ginkgolic acid C17:1 double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.093 mM, for A-549 cell 0.050 mM, for HL-60 cell 0.004 mM Homo sapiens
ginkgolic acid C17:2 double bond positions not specified Gallus gallus
ginkgolic acid C17:2 double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.108 mM, for A-549 cell 0.056 mM, for HL-60 cell 0.004 mM Homo sapiens
luteolin
-
 Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
liver
-
 Gallus gallus
-
MCF-7 cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C17:2
0.01
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C17:1
0.013
-
 pH 7.0, 37°C Gallus gallus cerulenin
0.017
-
 pH 7.0, 37°C Gallus gallus ginkgolic acid C15:1
0.062
-
 pH 7.0, 37°C Gallus gallus luteolin