Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.85 extracted from

  • Grunt, T.W.; Wagner, R.; Grusch, M.; Berger, W.; Singer, C.F.; Marian, B.; Zielinski, C.C.; Lupu, R.
    Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells (2009), Biochem. Biophys. Res. Commun., 385, 454-459.
    View publication on PubMed
Search for more literature for 2.3.1.85

Inhibitors

Inhibitors Comment Organism Structure
C75 FASN inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
 Homo sapiens
-
ovarian cancer cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
FASN
-
 Homo sapiens
fatty acid synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens C75 downregulates FASN mRNA in A2780 with an IC50 after 3d of 0.00525 mg/ml and an IT50 (time required for 50% inhibition) at 0.007 mg/ml of 21.5 h. This corresponds with FASN protein downregulation (IC50 = 0.00415 mg/ml), although the dynamics are slower (IT50 = 40 h). Pelitinib, given for 3d, abrogates FASN mRNA and protein in A-2780 cellsat doses as low as 0.003 mM down
Homo sapiens fatty acid synthase is overexpressed in ovarian cancer up

General Information

General Information Comment Organism
physiological function FASN produces phospholipids for membrane microdomains that accommodate receptor tyrosine kinases including epidermal growth factor-receptor ErbB1 and ErbB2 Homo sapiens