Crystallization (Comment) | Organism |
---|---|
of thioesterase domain, which comprises two dissimilar subdomains A and B | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A2419L | 97% reduction of thioesterase activity | Homo sapiens |
A2419M | 92% reduction of thioesterase activity | Homo sapiens |
F2371W | 20% reduction of thioesterase activity | Homo sapiens |
F2423A | 67% reduction of thioesterase activity | Homo sapiens |
F2423W | 24% reduction of thioesterase activity | Homo sapiens |
I2250W | 97% reduction of thioesterase activity | Homo sapiens |
K2426A | 99% reduction of thioesterase activity | Homo sapiens |
S2422A | 7% reduction of thioesterase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49327 | thioesterase domain of enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Homo sapiens | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |