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Literature summary for 2.3.1.85 extracted from

  • Chirala, S.S.; Chang, H.; Matzuk, M.; Abu-Elheiga, L.; Mao, J.; Mahon, K.; Finegold, M.; Wakil, S.J.
    Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero (2003), Proc. Natl. Acad. Sci. USA, 100, 6358-6363.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout mutants, heterozygous mutant animals are ostensibly normal, with about 50% reduction in enzyme mRNA and 35% reduction in enzyme activity. Partial haploid insufficieny in heterozygous animals, most embryos die at various stages of development. No production of enzyme homozygous mutant animals Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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