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Literature summary for 2.3.1.85 extracted from

  • Tsukamoto, Y.; Wong, H.; Mattick, J.S.; Wakil, S.J.
    The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action (1983), J. Biol. Chem., 258, 15312-15322.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cerulenin acetyl-CoA protects Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
molecular weight of fragments after proteolytic cleavage Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Gallus gallus
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2 1.6 NADPH Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
?

Subunits

Subunits Comment Organism
More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis and an acyl carrier site, arranged in three domains Gallus gallus

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine
-
Gallus gallus