Literature summary for 2.3.1.82 extracted from

Chiem, K.; Jani, S.; Fuentes, B.; Lin, D.; Rasche, M.; Tolmasky, M.
Identification of an inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] by glide molecular docking (2016), MedChemComm, 7, 184-189 .

Search for more literature for 2.3.1.82

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[3-(2-aminoethyl)benzyl]-3-(piperidin-1-ylmethyl)pyrrolidin-3-ol	the growth of an amikacin-resistant Acinetobacter baumannii clinical strain is inhibited in the presence of a combination of amikacin and compound	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	Q6SJ71	-	-

Synonyms

Synonyms	Comment	Organism
AAC(6')-Ib	-	Escherichia coli
aminoglycoside 6'-N-acetyltransferase type Ib	-	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0349	-	substrate amikacin, pH not specified in the publication, temperature not specified in the publication	Escherichia coli	1-[3-(2-aminoethyl)benzyl]-3-(piperidin-1-ylmethyl)pyrrolidin-3-ol
0.0397	-	substrate kanamycin A, pH not specified in the publication, temperature not specified in the publication	Escherichia coli	1-[3-(2-aminoethyl)benzyl]-3-(piperidin-1-ylmethyl)pyrrolidin-3-ol

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)