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Literature summary for 2.3.1.61 extracted from

  • Kanamori, T.; Nishimaki, K.; Asoh, S.; Ishibashi, Y.; Takata, I.; Kuwabara, T.; Taira, K.; Yamaguchi, H.; Sugihara, S.; Yamazaki, T.; Ihara, Y.; Nakano, K.; Matuda, S.; Ohta, S.
    Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain (2003), EMBO J., 22, 2913-2923.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the DLST gene is bifunctionally involved in mitochondrial energy metabolism, the full-length DLST protein is involved in the Krebs cycle and the truncated version, MIRTD, contributes to the biogenesis of the respiratory chain. The genotype of the DLST gene is associated with Alztheimer‘s disease without a change of amino acid residues in the DLST protein: through a decrease in the expression of the truncated gene product MIRTD and the function of MIRTD. It remains unclear how much MIRTD actually contributes to the pathogenesis of Alzheimer‘s disease ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the DLST gene is bifunctionally involved in mitochondrial energy metabolism, the full-length DLST protein is involved in the Krebs cycle and the truncated version, MIRTD, contributes to the biogenesis of the respiratory chain. The genotype of the DLST gene is associated with Alztheimer‘s disease without a change of amino acid residues in the DLST protein: through a decrease in the expression of the truncated gene product MIRTD and the function of MIRTD. It remains unclear how much MIRTD actually contributes to the pathogenesis of Alzheimer‘s disease Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
DLST
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Homo sapiens