Literature summary for 2.3.1.61 extracted from

Knapp, J.E.; Carroll, D.; Lawson, J.E.; Ernst, S.R.; Reed, L.J.; Hackert, M.L.
Expression, purification, and structural analysis of the trimeric form of the catalytic domain of the Escherichia coli dihydrolipoamide succinyltransferase (2000), Protein Sci., 9, 37-48.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37000	-	3 * 37000, E2o is normally a 24-mer, found as a trimer, when E2o is expressed with a C-terminal [His]6 tag, SDS-PAGE	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + dihydrolipoamide	Haemophilus influenzae	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Homo sapiens	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Saccharomyces cerevisiae	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Geobacillus stearothermophilus	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Pseudomonas aeruginosa	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Enterococcus faecalis	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Azotobacter vinelandii	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Cupriavidus necator	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Corynebacterium glutamicum	-	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	Escherichia coli	-	CoA + S-succinyldihydrolipoamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Azotobacter vinelandii	-	-	-
Corynebacterium glutamicum	Q8NNJ2	synonym Brevibacterium lactofermentum	-
Cupriavidus necator	-	-	-
Enterococcus faecalis	-	-	-
Escherichia coli	P0AFG6	-	-
Geobacillus stearothermophilus	-	-	-
Haemophilus influenzae	-	-	-
Homo sapiens	-	-	-
Pseudomonas aeruginosa	-	-	-
Saccharomyces cerevisiae	-	yeast	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + dihydrolipoamide	-	Haemophilus influenzae	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Homo sapiens	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Saccharomyces cerevisiae	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Geobacillus stearothermophilus	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Pseudomonas aeruginosa	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Enterococcus faecalis	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Azotobacter vinelandii	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Cupriavidus necator	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Corynebacterium glutamicum	CoA + S-succinyldihydrolipoamide	-	?
succinyl-CoA + dihydrolipoamide	-	Escherichia coli	CoA + S-succinyldihydrolipoamide	-	?

Subunits

Subunits	Comment	Organism
trimer	3 * 37000, E2o is normally a 24-mer, found as a trimer, when E2o is expressed with a C-terminal [His]6 tag, SDS-PAGE	Escherichia coli

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Release 2023.1 (January 2023)