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Literature summary for 2.3.1.54 extracted from

  • Himo, F.; Eriksson, L.A.
    Catalytic mechanism of pyruvate formate-lyase (PFL). A theoretical study (1998), J. Am. Chem. Soc., 120, 11449-11455.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA Escherichia coli key enzyme of the glucose fermentation route in anaerobically growing cells acetyl-CoA + formate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA
-
Escherichia coli acetyl-CoA + formate
-
r
pyruvate + CoA key enzyme of the glucose fermentation route in anaerobically growing cells Escherichia coli acetyl-CoA + formate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.33
-
formate backward direction Escherichia coli
12.8
-
pyruvate forward direction Escherichia coli