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Literature summary for 2.3.1.50 extracted from

  • Lowther, J.; Yard, B.A.; Johnson, K.A.; Carter, L.G.; Bhat, V.T.; Raman, M.C.; Clarke, D.J.; Ramakers, B.; McMahon, S.A.; Naismith, J.H.; Campopiano, D.J.
    Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation (2010), Mol. Biosyst., 6, 1682-1693.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged protein expressed in Escherichia coli BL21(DE3) Sphingomonas paucimobilis

Crystallization (Commentary)

Crystallization (Comment) Organism
after incubation with L-cycloserine Sphingomonas paucimobilis

Protein Variants

Protein Variants Comment Organism
R378N residue highly mobile, activity 40fold reduced Sphingomonas paucimobilis

Inhibitors

Inhibitors Comment Organism Structure
4-amino-3-isoxazolidone D-cycloserine and L-cycloserine are inhibitors, L-cycloserine is 14-fold more effective than D-cycloserine Sphingomonas paucimobilis

Organism

Organism UniProt Comment Textmining
Sphingomonas paucimobilis Q93UV0
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography (Ni2+), gel filtration Sphingomonas paucimobilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + palmitoyl-CoA
-
Sphingomonas paucimobilis CoA + 3-dehydro-D-sphinganine + CO2
-
?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Sphingomonas paucimobilis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Sphingomonas paucimobilis