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Literature summary for 2.3.1.50 extracted from

  • Takahashi, Y.; Berberich, T.; Kanzaki, H.; Matsumura, H.; Saitoh, H.; Kusano, T.; Terauchi, R.
    Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance (2009), Mol. Plant Microbe Interact., 22, 31-38.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
subunit LCB1, DNA and amino acid sequence determination and analysis Nicotiana benthamiana
subunit LCB2 Nicotiana benthamiana

Protein Variants

Protein Variants Comment Organism
additional information reduced sphingolipid synthesis resulting from suppression of NbLCB2 expression interferes with normal leaf morphogenesis. NbLCB2 overexpression causes a cell death phenotype in Nicotiana benthamiana leaves. Downregulation of the genes encoding for the enzyme subunits compromises pathogen resistance against Pseudomonas cichorii Nicotiana benthamiana
additional information the phenotype of NbLCB1-silenced plants is almost the same as the control except for a slight downward curling of leaf edges in NbLCB1-silenced plants. Downregulation of the genes encoding for the enzyme subunits compromises pathogen resistance against Pseudomonas cichorii Nicotiana benthamiana

Inhibitors

Inhibitors Comment Organism Structure
myriocin inhibits the enzyme and inhibits defense response against a nonhost pathogen; inhibits the enzyme and inhibits defense response against a nonhost pathogen Nicotiana benthamiana

Organism

Organism UniProt Comment Textmining
Nicotiana benthamiana B3Y000 subunit LCB2; two genes encoding the LCB2 and LCB1 subunits of the enzyme
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Nicotiana benthamiana B3Y9H2 subunit LCB1 fragment; two genes encoding the LCB2 and LCB1 subunits of the enzyme
-

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Nicotiana benthamiana
SPT
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Nicotiana benthamiana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate the pyridoxal 5'-phosphate binding site is required for the LCB2 gene cell death inducing function Nicotiana benthamiana

Expression

Organism Comment Expression
Nicotiana benthamiana Pseudomonas cichorii infection induces expression of subunit LCB2 up

General Information

General Information Comment Organism
physiological function the enzyme is required for resistance against pathogen Pseudomonas cichorii. The gene for the LCB2 subunit of SPT is a potent inducer of hypersensitive response-like cell death involving pyridoxal 5'-phosphate Nicotiana benthamiana