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Literature summary for 2.3.1.50 extracted from

  • Ruetti, M.F.; Richard, S.; Penno, A.; von Eckardstein, A.; Hornemann, T.
    An improved method to determine serine palmitoyltransferase activity (2009), J. Lipid Res., 50, 1237-1244.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by sucrose monolaurate Homo sapiens
palmitoyl-CoA causes substrate inhibition at higher concentrations Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics Homo sapiens
1.2
-
L-serine pH 8.0, 37°C, microsomes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens first and rate-limiting step in the de novo synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000465
-
activity in microsomes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information assay optimization measuring radio-labeled L-serine incorporation into 3-oxodihydrosphingosine in microsomes or crude cell lysate, usage of an nonradioactive HPLC-based detection protocol, overview Homo sapiens ?
-
?
palmitoyl-CoA + L-serine
-
Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
?
palmitoyl-CoA + L-serine first and rate-limiting step in the de novo synthesis of sphingolipids Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Homo sapiens
SPT
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

General Information

General Information Comment Organism
metabolism SPT catalyzes the first and rate-limiting step in the de novo synthesis of sphingolipids Homo sapiens