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Literature summary for 2.3.1.50 extracted from

  • Carton, J.M.; Uhlinger, D.J.; Batheja, A.D.; Derian, C.; Ho, G.; Argenteri, D.; D'Andrea, M.R.
    Enhanced serine palmitoyltransferase expression in proliferating fibroblasts, transformed cell lines, and human tumors (2003), J. Histochem. Cytochem., 51, 715-726.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol in quiescent cells Homo sapiens 5829
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nucleus nuclear association in proliferating cells Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens the enzyme catalyzes the initial and rate-limiting step in de novo sphingolipid synthesis. Potential role for overexpression of SPT in processes of cell metastasis CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell strong overexpression of both SPT subunits Homo sapiens
-
fibroblast proliferating, neonatal, dermal Homo sapiens
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leiomyosarcoma cell strong overexpression of both SPT subunits Homo sapiens
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ovary cancer cell strong overexpression of both SPT subunits Homo sapiens
-
pancreatic cancer cell strong overexpression of both SPT subunits Homo sapiens
-
sarcoma cell strong overexpression of both SPT subunits Homo sapiens
-
thyroid cancer cell strong overexpression of both SPT subunits Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine the enzyme catalyzes the initial and rate-limiting step in de novo sphingolipid synthesis. Potential role for overexpression of SPT in processes of cell metastasis Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
?

Synonyms

Synonyms Comment Organism
SPT
-
Homo sapiens