Activating Compound | Comment | Organism | Structure |
---|---|---|---|
etoposide | - |
Homo sapiens | |
etoposide | activates enzyme activity, but decreases mRNA level, time-dependent | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
RT-PCR from mRNA of Molt-4 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | time-dependent degradation of enzyme mRNA by etoposide, activation of enzyme activity on protein level, time-dependent; time-dependent degradation of enzyme mRNA by etoposide, activation of enzyme activity on protein level, time-dependent | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | Homo sapiens | - |
CoA + 3-dehydro-D-sphinganine + CO2 | - |
ir | |
palmitoyl-CoA + L-serine | Homo sapiens | first step of biosynthesis of sphingolipid bases | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | Homo sapiens | rate-limiting enzyme in synthesis of sphingolipids | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | Homo sapiens | initial step of de novo ceramide biosynthesis | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | O15269 | gene hLCB1 | - |
Homo sapiens | O15270 | gene hLCB2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | leukemia Molt-4 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-serine | - |
Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | - |
Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
ir | |
palmitoyl-CoA + L-serine | first step of biosynthesis of sphingolipid bases | Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | rate-limiting enzyme in synthesis of sphingolipids | Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | initial step of de novo ceramide biosynthesis | Homo sapiens | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Homo sapiens |