Cloned (Comment) | Organism |
---|---|
gene gcn5 | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of gcn5 mutant plants which show serious defects in thermotolerance under heat-stress treatment conditions. 5% of the gcn5 seedlings recover when exposed to 38°C for 4 days compared to 55% of the wild-type plants. GCN5 mutation induces extensive changes in gene expression patterns under heat stress, overview. The expression levels of hsp101, HSP90.1, HSP70, HSP70b, HSP70T and genes encoding small heat shock proteins are decreased in the gcn5 mutant. Constitutive UVH6 expression in gcn5 mutant plants partially restores heat tolerance | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Arabidopsis thaliana | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Arabidopsis thaliana | acetylation at Lys9 | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | Arabidopsis thaliana | acetylation at Lys14 | CoA + acetylhistone H4 | - |
? | |
additional information | Arabidopsis thaliana | GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
gene Gcn5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seedling | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation at Lys9 | Arabidopsis thaliana | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | acetylation at Lys14 | Arabidopsis thaliana | CoA + acetylhistone H4 | - |
? | |
additional information | GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gcn5 | - |
Arabidopsis thaliana |
HAT | - |
Arabidopsis thaliana |
Organism | Comment | Expression |
---|---|---|
Arabidopsis thaliana | quantitative RT-PCR analysis of the expression of HAT family genes in response to hest stress, overview | additional information |
Arabidopsis thaliana | enzyme GCN5 is upregulated by heat stress | up |
General Information | Comment | Organism |
---|---|---|
evolution | the Arabidopsis genome contains 12 histone acetyltransferase genes | Arabidopsis thaliana |
malfunction | loss of function of the Arabidopsis histone acetyltransferase GCN5 results in serious defects in terms of thermotolerance, and considerably impairs the transcriptional activation of heat stress-responsive genes. The expression of several key regulators such as the heat stress transcription factors HSFA2 and HSFA3, multiprotein bridging factor 1c (MBF1c) and UV-hypersensitive 6 (UVH6) is downregulated in the gcn5 mutant under heat stress compared with the wild-type. The GCN5 mutation affects H3K9 and H3K14 acetylation of HSFA3 and UVH6 genes under heat stress. Overexpression of the Triticum aestivum TaGCN5 gene restores thermotolerance in Arabidopsis gcn5 mutant plants | Arabidopsis thaliana |
physiological function | GCN5 is an important histone acetyltransferase that is required for gene expression changes involved in numerous plant development pathways and responses to environmental conditions in Arabidopsis. Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis thaliana | Arabidopsis thaliana |