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Literature summary for 2.3.1.48 extracted from

  • Zheng, X.; Gai, X.; Ding, F.; Lu, Z.; Tu, K.; Yao, Y.; Liu, Q.
    Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling (2013), Mol. Cancer, 12, 96.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the enzyme is bound to histone H4 in the nucleus of Hep-3B cells Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H4 Homo sapiens
-
 CoA + acetylhistone H4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatocellular carcinoma cell P300/CBP-associated factor expression level analysis Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
PLC/PRF/5 cell
-
 Homo sapiens
-
SK-HEP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4
-
 Homo sapiens CoA + acetylhistone H4
-
 ?
acetyl-CoA + histone H4 the enzyme PCAF acetylates histone H4 at lysine 8 Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

Synonyms Comment Organism
P300/CBP-associated factor
-
 Homo sapiens
PCAF
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction forced expression of PCAF inhibits the growth of hepatocellular carcinoma xenografts, upregulates histone H4 acetylation, suppresses phosphorylation of AKT, and accelerates cell apoptosis. Knockdown of PCAF represses cell apoptosis and accelerates proliferation in Hep-3B cells. Enzyme downregulation in hepatocellular carcinoma tissues is significantly correlated with tumor TNM staging and intrahepatic metastasis Homo sapiens
physiological function enzyme PCAF promotes cell apoptosis and functions as a hepatocellular carcinoma repressor through acetylation of histone H4 and inactivation of AKT signaling. Enzyme PCAF regulates acetylation of histone H4 and phosphorylation of AKT in HCC Homo sapiens