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Literature summary for 2.3.1.48 extracted from

  • Inagaki, Y.; Shiraki, K.; Sugimoto, K.; Yada, T.; Tameda, M.; Ogura, S.; Yamamoto, N.; Takei, Y.; Ito, M.
    Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity (2016), Int. J. Oncol., 48, 533-540.
    View publication on PubMed
Search for more literature for 2.3.1.48

Application

Application Comment Organism
medicine CBP/p300 could be a promising therapeutic target in hepatocellular carcinoma Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
C646 CBP/p300-specific histone acetyltransferase inhibitor, that inhibits proliferation of hepatocellular carcinoma cell lines in a dose-dependent manner; CBP/p300-specific histone acetyltransferase inhibitor, that inhibits proliferation of hepatocellular carcinoma cell lines in a dose-dependent manner Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q09472 p300
-
Homo sapiens Q92793 CBP
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocarcinoma cell high expression öevel of CBP/p300 in hepatocarcinoma tissue Homo sapiens
-
hepatoma HLE cell
-
 Homo sapiens
-
SK-HEP-1 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
CREB binding protein
-
 Homo sapiens
HAT
-
 Homo sapiens
p300
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition significantly augments TRAIL-induced apoptotic sensitivity, which is accompanied by reduced levels of survivin, in Hep-G2, HLE and SK-HEP1 cells. Enzyme inhibition significantly decreases invasion of Huh7, HLE and SK-HEP1 cells. The level of matrix metallopeptidase 15 (MMP15) mRNA expression is significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression is significantly increased in Huh7 cells following exposure to enzyme inhibitor C646 Homo sapiens
physiological function expression of p300, but not of CBP, is strongly correlated with the malignant character of hepatocellular carcinoma. CBP/p300 HAT activity has an important role in malignant transformation, proliferation, apoptotic sensitivity and invasion in hepatocellular carcinoma Homo sapiens