Cloned (Comment) | Organism |
---|---|
gene KAT2B, in vivo gene expression profiling | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | contribution of PCAF to post-ischemic neovascularization in a hind limb ischemia model23, using enzyme-deficient PCAF-/- mice, phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
garcinol | after induction of hind limb ischemia, blood flow recovery is impaired in both PCAF-/- mice and healthy wild type mice treated with the pharmacological PCAF inhibitor garcinol | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JHD1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Kat2b | - |
Mus musculus |
P300/CBP-associated factor | - |
Mus musculus |
PCAF | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | tehe enzyme belongs to the p300/CBP enzyme family | Mus musculus |
malfunction | PCAF deficiency reduces the in vitro inflammatory response in leukocytes and vascular cells involved in arteriogenesis. PCAF deficiency results in differential expression of 3505 genes during arteriogenesis and, more specifically, in impaired induction of multiple proinflammatory genes. Recruitment from the bone marrow of inflammatory cells, in particular proinflammatory Ly6Chi monocytes, is severely impaired in PCAF-/- mice | Mus musculus |
physiological function | an important role for PCAF in arteriogenesis. Enzyme PCAF modulates post-ischemic gene regulation | Mus musculus |