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Literature summary for 2.3.1.48 extracted from

  • Bastiaansen, A.J.; Ewing, M.M.; de Boer, H.C.; van der Pouw Kraan, T.C.; de Vries, M.R.; Peters, E.A.; Welten, S.M.; Arens, R.; Moore, S.M.; Faber, J.E.; Jukema, J.W.; Hamming, J.F.; Nossent, A.Y.; Quax, P.H.
    Lysine acetyltransferase PCAF is a key regulator of arteriogenesis (2013), Arterioscler. Thromb. Vasc. Biol., 33, 1902-1910.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene KAT2B, in vivo gene expression profiling Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information contribution of PCAF to post-ischemic neovascularization in a hind limb ischemia model23, using enzyme-deficient PCAF-/- mice, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
garcinol after induction of hind limb ischemia, blood flow recovery is impaired in both PCAF-/- mice and healthy wild type mice treated with the pharmacological PCAF inhibitor garcinol Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JHD1
-
-

Synonyms

Synonyms Comment Organism
Kat2b
-
Mus musculus
P300/CBP-associated factor
-
Mus musculus
PCAF
-
Mus musculus

General Information

General Information Comment Organism
evolution tehe enzyme belongs to the p300/CBP enzyme family Mus musculus
malfunction PCAF deficiency reduces the in vitro inflammatory response in leukocytes and vascular cells involved in arteriogenesis. PCAF deficiency results in differential expression of 3505 genes during arteriogenesis and, more specifically, in impaired induction of multiple proinflammatory genes. Recruitment from the bone marrow of inflammatory cells, in particular proinflammatory Ly6Chi monocytes, is severely impaired in PCAF-/- mice Mus musculus
physiological function an important role for PCAF in arteriogenesis. Enzyme PCAF modulates post-ischemic gene regulation Mus musculus