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Literature summary for 2.3.1.48 extracted from

  • Gomez, E.B.; Nugent, R.L.; Laria, S.; Forsburg, S.L.
    Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation (2008), Genetics, 179, 757-771.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information isolation of a temperature-sensitive allele of the essential mst gene. Mutant mst1 cells show a pleiotropic phenotype at the restrictive temperature. They are sensitive to a variety of DNA-damaging agents and to the spindle poison thiabendazole. Mutant mst1 has an increased frequency of Rad22 repair foci, suggesting endogenous damage, overview Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Schizosaccharomyces pombe Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview ?
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Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
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diverse strains, overview
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview Schizosaccharomyces pombe ?
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Synonyms

Synonyms Comment Organism
KAT5
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Schizosaccharomyces pombe
More Mst1 is a member of the MYST family of histone acetyltransferases and is the likely orthologue of Saccharomyces cerevisiae Esa1 and human Tip60, i.e. KAT5 Schizosaccharomyces pombe
Mst1
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Schizosaccharomyces pombe

General Information

General Information Comment Organism
physiological function Mst1 is essentially required for damage response and chromosome segregation, it plays essential roles in maintenance of genome stability and recovery from DNA damage Schizosaccharomyces pombe