Protein Variants | Comment | Organism |
---|---|---|
K56Q | mutation of the acetylation site of histone H3, the mutant shows CAG repeat contractions similar to the wild-type enzyme | Saccharomyces cerevisiae |
K56R | mutation of the acetylation site of histone H3, regulation of H3K56 acetylation plays a role in preventing CAG repeat contractions, but may not account for the full effect of deleting the RTT109 gene | Saccharomyces cerevisiae |
additional information | mutant cells lacking RTT109 have a high level of CAG/CTG repeat contractions and a twofold increase in breakage at CAG/CTG repeats. Dnl4 and Rad51-dependent pathways do play a role in creating some of the repeat contractions in rtt109-deficient cells | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Saccharomyces cerevisiae | acetylation of Lys56 | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | Saccharomyces cerevisiae BY4705 | acetylation of Lys56 | CoA + acetylhistone H3 | - |
? | |
additional information | Saccharomyces cerevisiae | Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner | ? | - |
? | |
additional information | Saccharomyces cerevisiae BY4705 | Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae BY4705 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation of Lys56 | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | acetylation of Lys56 | Saccharomyces cerevisiae BY4705 | CoA + acetylhistone H3 | - |
? | |
additional information | Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner | Saccharomyces cerevisiae | ? | - |
? | |
additional information | Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner | Saccharomyces cerevisiae BY4705 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rtt109 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | cells lacking RTT109 have a high level of CAG/CTG repeat contractions and a twofold increase in breakage at CAG/CTG repeats | Saccharomyces cerevisiae |
physiological function | role for Rtt109 and H3K56 acetylation in maintaining repetitive DNA sequences in Saccharomyces cerevisiae | Saccharomyces cerevisiae |