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Literature summary for 2.3.1.48 extracted from

  • Yang, J.H.; Freudenreich, C.H.
    The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions (2010), DNA Repair, 9, 414-420.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K56Q mutation of the acetylation site of histone H3, the mutant shows CAG repeat contractions similar to the wild-type enzyme Saccharomyces cerevisiae
K56R mutation of the acetylation site of histone H3, regulation of H3K56 acetylation plays a role in preventing CAG repeat contractions, but may not account for the full effect of deleting the RTT109 gene Saccharomyces cerevisiae
additional information mutant cells lacking RTT109 have a high level of CAG/CTG repeat contractions and a twofold increase in breakage at CAG/CTG repeats. Dnl4 and Rad51-dependent pathways do play a role in creating some of the repeat contractions in rtt109-deficient cells Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Saccharomyces cerevisiae acetylation of Lys56 CoA + acetylhistone H3
-
?
acetyl-CoA + histone H3 Saccharomyces cerevisiae BY4705 acetylation of Lys56 CoA + acetylhistone H3
-
?
additional information Saccharomyces cerevisiae Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner ?
-
?
additional information Saccharomyces cerevisiae BY4705 Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae BY4705
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 acetylation of Lys56 Saccharomyces cerevisiae CoA + acetylhistone H3
-
?
acetyl-CoA + histone H3 acetylation of Lys56 Saccharomyces cerevisiae BY4705 CoA + acetylhistone H3
-
?
additional information Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner Saccharomyces cerevisiae ?
-
?
additional information Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner Saccharomyces cerevisiae BY4705 ?
-
?

Synonyms

Synonyms Comment Organism
Rtt109
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction cells lacking RTT109 have a high level of CAG/CTG repeat contractions and a twofold increase in breakage at CAG/CTG repeats Saccharomyces cerevisiae
physiological function role for Rtt109 and H3K56 acetylation in maintaining repetitive DNA sequences in Saccharomyces cerevisiae Saccharomyces cerevisiae