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Literature summary for 2.3.1.48 extracted from

  • Perez-Campo, F.M.; Borrow, J.; Kouskoff, V.; Lacaud, G.
    The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors (2009), Blood, 113, 4866-4874.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged wild-type and mutant enzymes using the baculovrius transfection system Mus musculus

Protein Variants

Protein Variants Comment Organism
G657E site-directed mutagenesis, loss-of-function mutation in the HAT catalytic domain of MOZ, mutation of the HAT catalytic domain affects B-lineage differentiation and hematopoietic stem/progenitor cell frequencies, analysis of hematopoietic cell populations in HAT-/-, HAT-/+, and HAT+/+ mice, overview. The HAT activity of MOZ is essential for maintaining the functionality of hematopoietic stem cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
224000
-
Moz Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required ?
-
?
additional information Mus musculus C57BL/6 specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged wild-type and mutant enzymes by nickel affinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
Mus musculus
-
bone marrow
-
Mus musculus
-
embryonic stem cell E14.1, 129/Ola cells Mus musculus
-
erythroid progenitor cell
-
Mus musculus
-
liver fetal Mus musculus
-
macrophage
-
Mus musculus
-
spleen
-
Mus musculus
-
T-cell
-
Mus musculus
-
thymus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H2A
-
Mus musculus CoA + acetylhistone H2A
-
?
acetyl-CoA + histone H2A
-
Mus musculus C57BL/6 CoA + acetylhistone H2A
-
?
additional information specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required Mus musculus ?
-
?
additional information specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required Mus musculus C57BL/6 ?
-
?

Subunits

Subunits Comment Organism
More MOZ encodes a large multidomain protein that contains, among others, 2 domains shown to interact with the transcription factor Runx1, a C4H3 domain also referred to as plant homeodomain, an atypical Cys(2)-His-Cys (C2HC) zinc finger domain with a putative nucleosome-binding activity, and a region with homology to the active acetyl-CoA binding site of several HAT proteins Mus musculus

Synonyms

Synonyms Comment Organism
HAT
-
Mus musculus
histone acetyl transferase
-
Mus musculus
monocytic leukemia zinc finger
-
Mus musculus
More MOZ is the founding member of the MOZ, Ybf2/Sas2, Tip60 , i.e. MYST family of HATs, characterized by the presence of a conserved MYST domain that comprises both the C2HC nucleosome-binding domain and the putative HAT domain Mus musculus
MOZ
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme activity of MOZ is critical for the proliferation of hematopoietic precursors, overview Mus musculus