Cloned (Comment) | Organism |
---|---|
expression of His-tagged wild-type and mutant enzymes using the baculovrius transfection system | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G657E | site-directed mutagenesis, loss-of-function mutation in the HAT catalytic domain of MOZ, mutation of the HAT catalytic domain affects B-lineage differentiation and hematopoietic stem/progenitor cell frequencies, analysis of hematopoietic cell populations in HAT-/-, HAT-/+, and HAT+/+ mice, overview. The HAT activity of MOZ is essential for maintaining the functionality of hematopoietic stem cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
224000 | - |
Moz | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required | ? | - |
? | |
additional information | Mus musculus C57BL/6 | specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged wild-type and mutant enzymes by nickel affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | - |
Mus musculus | - |
bone marrow | - |
Mus musculus | - |
embryonic stem cell | E14.1, 129/Ola cells | Mus musculus | - |
erythroid progenitor cell | - |
Mus musculus | - |
liver | fetal | Mus musculus | - |
macrophage | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
T-cell | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H2A | - |
Mus musculus | CoA + acetylhistone H2A | - |
? | |
acetyl-CoA + histone H2A | - |
Mus musculus C57BL/6 | CoA + acetylhistone H2A | - |
? | |
additional information | specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required | Mus musculus | ? | - |
? | |
additional information | specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required | Mus musculus C57BL/6 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | MOZ encodes a large multidomain protein that contains, among others, 2 domains shown to interact with the transcription factor Runx1, a C4H3 domain also referred to as plant homeodomain, an atypical Cys(2)-His-Cys (C2HC) zinc finger domain with a putative nucleosome-binding activity, and a region with homology to the active acetyl-CoA binding site of several HAT proteins | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Mus musculus |
histone acetyl transferase | - |
Mus musculus |
monocytic leukemia zinc finger | - |
Mus musculus |
More | MOZ is the founding member of the MOZ, Ybf2/Sas2, Tip60 , i.e. MYST family of HATs, characterized by the presence of a conserved MYST domain that comprises both the C2HC nucleosome-binding domain and the putative HAT domain | Mus musculus |
MOZ | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme activity of MOZ is critical for the proliferation of hematopoietic precursors, overview | Mus musculus |