Protein Variants | Comment | Organism |
---|---|---|
additional information | loss of HAT1 causes mild growth defects and increases sensitivities to methyl methanesulfonate and camptothecin. Stable expression of tagged Asf1 and C-terminally HA-Flag-tagged histone H4 in enzyme-deficient DT40 HAT-/- cells. Cytosolic Hat1-RbAp48 associate with histones H3 and H4, and Asf1 in vivo | Gallus gallus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic Hat1-RbAp48 associate with histones H3 and H4, and Asf1 in vivo | Gallus gallus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Gallus gallus | - |
CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | Gallus gallus | Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol | CoA + acetylhistone H4 | - |
? | |
additional information | Gallus gallus | histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DT-40 cell | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Gallus gallus | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | - |
Gallus gallus | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol | Gallus gallus | CoA + acetylhistone H4 | - |
? | |
additional information | histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview | Gallus gallus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hat1 | - |
Gallus gallus |
histone acetyltransferase-1 | - |
Gallus gallus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Gallus gallus |