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Literature summary for 2.3.1.48 extracted from

  • Tahan, F.; Jazrawi, E.; Moodley, T.; Rovati, G.E.; Adcock, I.M.
    Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity (2008), Clin. Exp. Allergy, 38, 805-811.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha a significant induction of NF-kB p65-associated HAT activity by TNF-alpha is demonstrated, which is attenuated by the presence of montelukast in a concentration-dependent manner Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
montelukast decreases HAT activity by attenuating the activating effect of TNF-alpha Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4
-
Homo sapiens CoA + acetylhistone H4
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Homo sapiens
histone acetyltransferase
-
Homo sapiens