Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of the hat1 gene from Schizosaccharomyces pombe causes increased sensitivity to the DNA-damaging agent methyl methanesulfonate in the absence of any additional mutations | Schizosaccharomyces pombe |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H4 + acetyl-CoA | Schizosaccharomyces pombe | - |
acetyl-histone H4 + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schizosaccharomyces pombe | Q9UTM7 | several strains, overview, gene HAT1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H4 + acetyl-CoA | - |
Schizosaccharomyces pombe | acetyl-histone H4 + CoA | - |
? | |
histone H4 + acetyl-CoA | acetylation at Lys5 and Lys12, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail | Schizosaccharomyces pombe | acetyl-histone H4 + CoA | - |
? | |
histone H4 N-terminal peptide + acetyl-CoA | N-terminal peptide of histone H4 of different length and sequence, prepared in HeLa cell extract, overview, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail, substituting glutamine for lysine at Lys8 and Lys16 dramatically reduces the ability of yHat1p to acetylate the H4 tail peptide, phosphorylation of Ser1 also reduces the acetylation of H4 peptides | Schizosaccharomyces pombe | acetyl-histone H4 N-terminal peptide + CoA | - |
? | |
additional information | substrate specificity and order of acetylation of histone H4 by Hat1, overview | Schizosaccharomyces pombe | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT-B | - |
Schizosaccharomyces pombe |
Hat1 | - |
Schizosaccharomyces pombe |
type B histone acetyltransferase | - |
Schizosaccharomyces pombe |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Schizosaccharomyces pombe |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Schizosaccharomyces pombe |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Schizosaccharomyces pombe |