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Literature summary for 2.3.1.48 extracted from

  • Trojer, P.; Dangl, M.; Bauer, I.; Graessle, S.; Loidl, P.; Brosch, G.
    Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity (2004), Biochemistry, 43, 10834-10843.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39366
-
x * 39366, RmtA, calculation from nucleotide sequence Aspergillus nidulans
61042
-
x * 61042, RmtB, calculation from nucleotide sequence Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone Aspergillus nidulans important role of the enzyme for chromatin modulating activity CoA + acetylhistone
-
?
acetyl-CoA + histone H4 Aspergillus nidulans RmtA is specific for histone H4 with Arg3 as the methylation site. Methylation of histone H4 by recombinant RmtA affects the acetylation by p300/CBP, supporting aninterrelation of histone methylation and acetylation in transcriptional regulation. Important role of the enzyme for chromatin modulating activity CoA + acetylhistone H4
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus nidulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone important role of the enzyme for chromatin modulating activity Aspergillus nidulans CoA + acetylhistone
-
?
acetyl-CoA + histone H2A
-
Aspergillus nidulans CoA + acetylhistone H2A
-
?
acetyl-CoA + histone H3
-
Aspergillus nidulans CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4
-
Aspergillus nidulans CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4 RmtA is specific for histone H4 with Arg3 as the methylation site. Methylation of histone H4 by recombinant RmtA affects the acetylation by p300/CBP, supporting aninterrelation of histone methylation and acetylation in transcriptional regulation. Important role of the enzyme for chromatin modulating activity Aspergillus nidulans CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4 RmtA is specific for histone H4 with Arg3 as the methylation site Aspergillus nidulans CoA + acetylhistone H4
-
?

Subunits

Subunits Comment Organism
? x * 39366, RmtA, calculation from nucleotide sequence Aspergillus nidulans
? x * 61042, RmtB, calculation from nucleotide sequence Aspergillus nidulans

Synonyms

Synonyms Comment Organism
arginine methyltransferase A
-
Aspergillus nidulans
arginine methyltransferase B
-
Aspergillus nidulans
RmtA
-
Aspergillus nidulans
RmtB
-
Aspergillus nidulans