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Literature summary for 2.3.1.48 extracted from
- Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60 (1997), J. Biol. Chem., 272, 30595-30598.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of Tip60 protein, which contains an evolutionary conserved domain with yeast silencing factor, as His-tagged protein in Escherichia coli and as GFP-fusion protein in COS cells | Human Immunodeficiency Virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human Immunodeficiency Virus | - |
recombinant from COS cell line and from Escherichia coli | - |
| Human Immunodeficiency Virus | - |
i.e. HIV | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged enzyme from E. coli | Human Immunodeficiency Virus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | acetylates histones H2A, H3, and H4, but not histone 2B | Human Immunodeficiency Virus | CoA + acetylhistone | - |
? |  |
| acetyl-CoA + histone H2A | - |
Human Immunodeficiency Virus | CoA + acetylhistone H2A | - |
? | |
| acetyl-CoA + histone H3 | - |
Human Immunodeficiency Virus | CoA + acetylhistone H3 | - |
? | |
| acetyl-CoA + histone H4 | - |
Human Immunodeficiency Virus | CoA + acetylhistone H4 | - |
? | |
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