Literature summary for 2.3.1.48 extracted from

Wong, L.J.; Patton, W.F.
Salt inhibition of nuclear histone acetyltransferase from calf thymus (1985), Int. J. Biochem., 17, 123-126.

Search for more literature for 2.3.1.48

Inhibitors

Inhibitors	Comment	Organism	Structure
(NH4)2SO4	competitive against both acetyl-CoA and histones	Bos taurus
additional information	monovalent cations cause a 50% decrease in activity at an average concentration of 51 mM, divalent cations at 15 mM	Bos taurus
Na+	competitive against both acetyl-CoA and histones	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + histone	-	Bos taurus	CoA + acetylhistone	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
8	-	(NH4)2SO4	versus acetyl-CoA	Bos taurus
12	-	(NH4)2SO4	versus histone	Bos taurus
30	-	Na+	versus acetyl-CoA	Bos taurus
34	-	Na+	versus histone	Bos taurus

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Release 2023.1 (January 2023)