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Literature summary for 2.3.1.48 extracted from
- Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities (1978), J. Biol. Chem., 253, 233-237.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | weak | Bos taurus |  |
| Mg2+ | no inhibition | Bos taurus | |
| Mn2+ | no inhibition | Bos taurus | |
| p-chloromercuribenzoate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
acetyl-CoA | - |
Bos taurus | |
| 0.2 | - |
spermidine | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Bos taurus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | addition of Mg2+ and Mn2+ has no effect on activity | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 150000 | - |
enzyme form A, gel filtration | Bos taurus |
| 175000 | - |
enzyme form B, gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Bos taurus | - |
2 enzyme forms: A and B | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from calf | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
| 0.00115 | - |
enzyme form A | Bos taurus |
| 0.0014 | - |
enzyme form B | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Bos taurus | CoA + acetylhistone | - |
? | |
| acetyl-CoA + spermidine | - |
Bos taurus | ? | - |
? | |
| acetyl-CoA + spermine | - |
Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Bos taurus |
| 8.7 | - |
spermidine | Bos taurus |
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Release 2023.1 (January 2023)
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