Application | Comment | Organism |
---|---|---|
synthesis | an effective metabolic engineering strategy for industrial polyunsaturated fatty acid production is provided | Schizochytrium sp. MYA1381 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] | Schizochytrium sp. MYA1381 | - |
CoA + a malonyl-[acyl-carrier protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schizochytrium sp. MYA1381 | A0A345ANG7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] | - |
Schizochytrium sp. MYA1381 | CoA + a malonyl-[acyl-carrier protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
malonyl-CoA: ACP transacylase | - |
Schizochytrium sp. MYA1381 |
MAT | - |
Schizochytrium sp. MYA1381 |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme overexpression can weaken tricarboxylic acid, accelerate glucose absorption by improving membrane fluidity and permeability, and enhance carbon flux to the polyunsaturated fatty acid synthesis. Lipid and polyunsaturated fatty acid concentrations are increased by 10.1 and 24.5% with enzyme overexpression, respectively. Docosahexaenoic acid and eicosapentaenoic acid yield are enhanced 81.5 and 172.5%, respectively | Schizochytrium sp. MYA1381 |
metabolism | lipid and polyunsaturated fatty acid concentration are increased by 10.1 and 24.5% with malonyl-CoA: ACP transacylase overexpression, respectively. The intracellular tricarboxylic acid cycle is weakened and glucose absorption is accelerated in the engineered strain. In the mevalonate pathway, intracellular carotene content is decreased, and the carbon flux is redirected toward synthesis of polyunsaturated fatty acid | Schizochytrium sp. MYA1381 |