Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | stimulates | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by sulfhydryl inhibitors | Escherichia coli | |
p-chloromercuribenzoate | strong | Escherichia coli | |
phenylmethanesulfonyl fluoride | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + acyl-carrier protein | Escherichia coli | initial reaction in de novo fatty acid synthesis, part of non-associated fatty acid synthase system of plants and prokaryotes | CoA + malonyl-acyl-carrier protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-cellulose and DEAE-Sephadex chromatography | Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein] | mechanism, formation of a malonyl-enzyme intermediate | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonyl-CoA + acyl-carrier protein | acetyl-CoA cannot replace malonyl-CoA | Escherichia coli | CoA + malonyl-[acyl-carrier protein] | - |
? | |
malonyl-CoA + acyl-carrier protein | characterization of acyl-carrier protein | Escherichia coli | CoA + malonyl-[acyl-carrier protein] | - |
? | |
malonyl-CoA + acyl-carrier protein | via stable covalent malonyl-enzyme intermediate | Escherichia coli | CoA + malonyl-[acyl-carrier protein] | - |
? | |
malonyl-CoA + acyl-carrier protein | initial reaction in de novo fatty acid synthesis, part of non-associated fatty acid synthase system of plants and prokaryotes | Escherichia coli | CoA + malonyl-acyl-carrier protein | - |
? | |
malonyl-CoA + pantetheine | - |
Escherichia coli | malonyl-pantetheine + CoA | - |
? | |
malonyl-pantetheine + acyl-carrier protein | - |
Escherichia coli | pantetheine + malonyl-[acyl-carrier protein] | - |
? |