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Literature summary for 2.3.1.199 extracted from

  • Oh, C.; Toke, D.; Mandala, S.; Martin, C.
    ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation (1997), J. Biol. Chem., 272, 17376-17384.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Saccharomyces cerevisiae 16020
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
very-long-chain acyl-CoA + malonyl-CoA
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Saccharomyces cerevisiae CoA + very-long-chain 3-oxoacyl-CoA + CO2
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Synonyms

Synonyms Comment Organism
Elo1p isozyme Saccharomyces cerevisiae
Elo2p isozyme Saccharomyces cerevisiae
Elo3p isozyme Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction null mutations in ELO3 result in accumulation of labeled precursors into inositol phosphoceramide, with little labeling in the more complex mannosylated sphingolipids, whereas disruption of ELO2 results in reduced levels of all sphingolipids. Mutations in ELO3 lead to elevated levels of C20 and C22 fatty acids (most abundant species is behenic acid which averages 3.1% of the total fatty acyl mass, a 10fold increase over wild type levels). ELO3 disruption results in an approximate 20% increase in the total levels of very long chain species. Sharply reduced levels of cerotic acid (approximately 20% wild type levels) and hydroxy-cerotic acid (approximately 40% of wild type levels) are found in an elo2 mutant strain Saccharomyces cerevisiae
physiological function Elo2p is involved in the elongation of fatty acids up to 24 carbons and has the highest affinity for substrates with chain lengths less than 22 carbons. Elo3p has a broader substrate specificity and is essential for the conversion of 24-carbon acids to 26-carbon species Saccharomyces cerevisiae