Application | Comment | Organism |
---|---|---|
molecular biology | dihydrolipoamide acetyltransferase is shown to be a metabolic longevity factor and is required for calorie restriction-mediated life span extension | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deleting the LAT1 gene abolishes life span extension induced by calorie restriction. Overexpressing Lat1 extends life span, and this life span extension is not further increased by calorie restriction. Similar to calorie restriction, life span extension by Lat1 overexpression largely requires mitochondrial respiration. Lat1 overexpression does not require the Sir2 family to extend life span, suggesting that Lat1 mediates a branch of the calorie restriction pathway that functions in parallel to the Sir2 family | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | Lat1 is a limiting longevity factor in nondividing cells. Overexpressing Lat1 extends cell survival during prolonged culture at stationary phase. Studies suggest that Lat1 overexpression extends life span by increasing metabolic fitness of the cell | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | A6ZS09 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Lat1 is a limiting longevity factor in nondividing cells. Overexpressing Lat1 extends cell survival during prolonged culture at stationary phase. Studies suggest that Lat1 overexpression extends life span by increasing metabolic fitness of the cell | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoamide acetyltransferase | E2 component of the mitochondrial pyruvate dehydrogenase complex | Saccharomyces cerevisiae |
dihydrolipoyl transacetylase | - |
Saccharomyces cerevisiae |
Lat1 | - |
Saccharomyces cerevisiae |
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component | - |
Saccharomyces cerevisiae |