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Literature summary for 2.2.1.6 extracted from
- Acetohydroxy acid synthase isoenzymes of Escherichia coli K12 and Salmonella typhimurium (1982), Ann. Microbiol., 133A, 251-256.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ile | mild inhibition of isoenzyme I and III | Escherichia coli |  |
| Ile | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Leu | no inhibition of isoenzyme I and III | Escherichia coli | |
| Leu | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
| Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Escherichia coli | |
| Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Salmonella enterica subsp. enterica serovar Typhimurium | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
| pyruvate | Escherichia coli | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
| pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu | ? | - |
? | |
| pyruvate | Escherichia coli | isoenzyme II is regulated by Leu | ? | - |
? | |
| pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
| pyruvate | Escherichia coli | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
| pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme I is regulated by Leu and Val | ? | - |
? | |
| pyruvate | Escherichia coli | isoenzyme I is regulated by Leu and Val | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
K-12 | - |
| Escherichia coli | - |
3 isoenzymes: I, II, and III | - |
| Escherichia coli | - |
isoenzyme I and III are expressed in wild type cells, isoenzyme II is cryptic | - |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
3 isoenzymes: I, II, and III | - |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
isoenzyme I and II are expressed in wild type cells, isoenzyme III is cryptic | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acetolactate + CO2 | - |
? | |
| pyruvate | - |
Escherichia coli | 2-acetolactate + CO2 | - |
? | |
| pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Escherichia coli | ? | - |
? | |
| pyruvate | isoenzyme II is regulated by Leu | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| pyruvate | isoenzyme II is regulated by Leu | Escherichia coli | ? | - |
? | |
| pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Escherichia coli | ? | - |
? | |
| pyruvate | isoenzyme I is regulated by Leu and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| pyruvate | isoenzyme I is regulated by Leu and Val | Escherichia coli | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
isoenzyme I | Salmonella enterica subsp. enterica serovar Typhimurium |
| 7 | - |
isoenzyme I | Escherichia coli |
| 8 | - |
isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium |
| 8 | - |
isoenzyme II | Escherichia coli |
| 9 | - |
isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium |
| 9 | - |
isoenzyme III | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | partial requirement for isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium | |
| FAD | absolutly required for isoenzyme I and II, no requirement for isoenzyme III | Escherichia coli | |
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